While C. albicans locked in the yeast form by constitutive expression of NRG1 (tet-NRG1) were avirulent in immunocompetent mice in this and previous studies14,74, the same strain was capable of inducing lethal infection in mice rendered leukopenic by combined treatment with cyclophosphamide and cortisone acetate75. The gene discussed is NRG1; the disease is infection.