SORT1 and gastric cancer: In our study, we discovered that hsa_circ_0110389 silencing could decrease SORT1 expression; in addition, we found that SORT1 overexpression significantly reversed the hsa_circ_0110389 knockdown induced suppression of proliferation, invasion and migration of GC cells, and SORT1 knockdown significantly blocked the hsa_circ_0110389 overexpression induced promotion of proliferation, invasion and migration in GC cells.