Increased γH2AX, Checkpoint kinase 2 (Chk2) protein phosphorylation, p53 were also reported in Down syndrome (DS) fibroblasts from both fetal and adult donors during unperturbed growth conditions [86], in the hippocampal neurons up to 14 days after laparotomy in elderly mice [87]. This evidence concerns the gene CHEK2 and Dravet syndrome.