L5, a human plasma low-density lipoprotein (LDL), fraction induces cell damage by activating ATM/H2AX-associated DNA breakage pathway and apoptosis via lectin-like oxidized LDL receptor-1 (LOX-1) signalling to p53, leading to cleavage of caspase-3, and to the development of neurodegenerative diseases including AD [81]. This evidence concerns the gene CASP3 and neurodegenerative disease.