In age-adjusted analysis we found no correlation between plasma IgA binding to peptide 17 and the risk of febrile malaria; however, for every 24% increase in IgG binding to peptide 17, there was a 50% reduction in the number of febrile malaria episodes (p = 0.01 after Bonferroni correction), suggesting that the MAD2-6 N-terminal epitope may be a relevant target of naturally acquired immunity to malaria. The gene discussed is CD79A; the disease is malaria.