Single i.m. immunizations with MVA-SARS-2-S already induced S269–278-epitope–specific activated CD8+ T cells with mean numbers of 341 IFN-γ spot-forming cells (SFCs) in 106 splenocytes for LD and 275 SFCs for HD compared to control mice immunized with nonrecombinant MVA (no SFCs detectable) (Fig. 4A). The gene discussed is IFNG; the disease is Huntington disease.