Given that DS affects the expression of NLRP3 inflammasome-associated proteins in activated BV-2 cells and CCI-induced neuropathic pain model mice, as well as DS or NLRP3 inflammasome inhibitor MCC950 and IL-1Ra all can ameliorate the neuropathic pain by increasing the mechanical withdrawal threshold, it is suggested that DS reduce the nociception likely via NLRP3 inflammasome mechanism. Here, NLRP3 is linked to neuropathic pain.