HDL-C exerts a protective role in the pathophysiological process of atherosclerosis formation and development [29], in which HDL-C plays anti-inflammatory and anti-oxidative roles and protects vascular endothelial cells by carried anti-oxidant enzymes such as paraoxonase-1(PON1), lecithin cholesterol acyltransferase(LCAT), and platelet-activating factor acetylhydrolase (PAF-AH). Here, PON1 is linked to atherosclerosis.