IGHE and toxic epidermal necrolysis: In fact, our overall results cannot be generalized to patients with potentially life‐threatening non‐IgE‐mediated index reactions (e.g., SJS/TEN)—in whom DPT is contraindicated—or to patients with positive penicillin skin tests, and we also identified that patients reporting an index anaphylactic reaction had almost 80 times more risk of developing severe reactions to DPT than the remaining participants.