Mice infected intranasally with 1.2 x 104 TCID50 (nCoV-19/Singapore/3/2020) presented with severe disease manifestations including lethargy, weight loss, overexpression of proinflammatory cytokines/chemokines (IL-6, CXCL10, and CCL2) and, ultimately, death between 6 and 8 days post infection (dpi) with associated high virus titers in lung tissue (S3 Fig). This evidence concerns the gene IL6 and infection.