In the present study, we analyzed whether polymorphisms in inflammasomes genes IL1B rs16944, IL18 rs187238, NLRP3 rs10754558, CARD8 rs2009373, CTSB rs1692816 and AIM2 rs1103577 are associated with susceptibility to HCV infection and liver fibrosis in hepatitis C patients in the Amazon population. This evidence concerns the gene IL18 and hepatitis C virus infection.