For example, miR-219 can modulate liver fibrosis by directly targeting tumor growth factor β receptor 2 (TGFBR2) [15], while miR-34a-5p targets Smad4 and modulates TGF-β1/Smad3 pathway in HSCs to ameliorate liver fibrosis [16]. Here, SMAD4 is linked to Hepatic fibrosis.