This observation is in agreement with the previously reported sequestration of a subset of transport factors by poly-GA (Khosravi et al., 2017; Solomon et al., 2018; Zhang et al., 2016), and the importin pathology that has been observed in postmortem frontal cortex tissue of ALS/FTD C9orf72 patients (Solomon et al., 2018). Here, C9orf72 is linked to amyotrophic lateral sclerosis.