Consistent with the findings of our study, TSA causes an increase in histone H3 acetylation level, while unexpectedly, the BRD4 inhibitor JQ1suppressed TSA‐mediated ESCC cell migration and attenuated TSA‐driven ERK1/2 phosphorylation as well as EMT. Here, BRD4 is linked to esophageal squamous cell carcinoma.