HK2 and rheumatoid arthritis: The changes in glucose metabolism are believed to contribute to disease progression of RA.[26,27] To date, recently published studies have shown that targeting the first step in glucose metabolism, HK2, could be a possible therapeutic target for RAFLSs.[11,12] However, to the best of our knowledge, there are no reports regarding the assessment of HK2 levels in PBMCs from patients with RA or OA.