In 2010, the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for RA, blood serum markers, such as CRP, ESR, ACPA (anti-carbamylated protein antibodies), RF, and anti-CCP antibodies, were adopted to diagnose RA or monitor disease activity.[28–30] However, they have limited value for the diagnosis of RA due to their relatively low specificity or sensitivity. This evidence concerns the gene PRTN3 and rheumatoid arthritis.