The levels of NSE and S100B protein were also affected by a variety of intracranial and extracranial factors and detection methods.[25]Although the levels of NSE and S100B were correlated with the degree and duration of consciousness impairment in patients with ACOP, they were not significantly different from the GCS score in predicting coma duration ≥ 72 hours in the ROC curve analysis (AUC of the 3 were 0.754, 0.791, and 0.785, respectively, P > .05). Here, S100B is linked to Coma.