The AUC of NSE to predict coma duration ≥ 72 hours was 0.754 [95% confidence interval (95% CI): 0.603–0.870]; the AUC of S100B to predict coma duration ≥ 72 hours was 0.791 (95% CI: 0.644–0.898), and the AUC of GCS score to predict coma duration ≥ 72 hours was 0.785 (95% CI: 0.637–0.893). This evidence concerns the gene ENO2 and Coma.