According to the extent of asparaginase exposure, previous studies reported that asparaginase-associated pancreatitis (AAP) may occur in 11% of pediatric patients with ALL.[4–7] Although premature asparaginase discontinuation may decrease cure rates,[7,8] AAP represents one of the most common reasons for asparaginase withdrawal in children. The gene discussed is ASPG; the disease is acute lymphoblastic leukemia.