Some data indicate that inhibition of the mitogen-activated protein kinase pathway increases chemosensitivity to glucocorticoids and possibly to other agents, making it an attractive target for the prevention and/or treatment of relapsed disease.[3] Here, we report a very rare case of Ph+ ALL and recurrent pancreatitis treated with trametinib combined with dasatinib. This evidence concerns the gene WNK2 and acute lymphoblastic leukemia.