TSHR and neoplasm: A similar increase of anti-TSH-R is frequently observed in RAI-treated GD patients and presumably, it is caused by the release of thyroid antigens during RAI-induced thyroid destruction.[22] However, during recurrence of the 8th right rib metastasis and after the second and third RAI application, the concentration of anti-TSH-R increased further, most likely as a reflection of tumor burden enlargement and the release of thyroid antigens after RAI therapy.