NFKB1 and metabolic syndrome: Among a variety of risk factors contributed to CAD, smoking and dyslipidemia are 2 most important risk factors, accounting for 2/3 of all risk factors.[49] Statins proved to be able to prevent nicotine effects by modulating activation of Rho A and NF-κB pathways.[50] The studies included in this meta-analysis report different proportions of smokers.