SIGLEC1 and infection: Importantly, the global phenotype of the ex vivo-infected PBMCs are in line with previous findings reported in ZIKV- and DENV-infected patients (16, 17, 19), such as upregulation of CD169 and CXCL10 in APC, and changes on monocyte phenotypes, validating the use of ex vivo infections to compare virus-induced phenotypes in blood cells.