Further results confirmed that the inhibition of VEGF expression by SCG2 inhibited angiogenesis in CRC tumors and also revealed that SCG2 interacted with VHL to promote VHL‐dependent degradation of HIF‐1α and block degradation of HIF‐1α, which attenuated the SCG2‐mediated decreased expression of VEGF. This evidence concerns the gene VEGFA and colorectal carcinoma.