The related genes, including TNFRSF13B, TNFRSF17, TNFRSF8, CCR7, NRP1, ENTPD1, LAG3, NRP1, TOX, and FOXP3, were also significantly upregulated and remarkably correlated to undesired prognosis in metastatic melanoma. The gene discussed is TNFRSF8; the disease is metastatic melanoma.