In summary, we demonstrated that elevated IL2RA,IL2RG, IL7R, and IFNG expression may facilitate melanoma metastasis through upregulation of tumor‐resident Treg‐cell proportion by activation of JAK—STAT signaling pathway, and determined four hub gene‐associated ceRNAs, as well as functionally metastasis‐relevant molecules including TNFRSF13B, TNFRSF17, CCR7, NRP1, NRP1, TOX, FOXP3, LAG3, NRP1, and so on. This evidence concerns the gene LAG3 and melanoma.