SHH and laurin-Sandrow syndrome: The mirror-image polydactyly of individual I11 shows striking phenotypic overlap with Laurin–Sandrow syndrome, which is caused by duplications of the SHH regulator ZRS, positioned in intron 5 of LMBR1 on chr7p36.3, resulting in ectopic expression of SHH in the embryonic limb (Lohan et al. 2014).