Indeed, deposition of complement activation products is a feature of both diabetes-related retinopathy (30) and nephropathy (31), although there is also evidence for lectin and classical pathway involvement; serum MBL levels are a strong biomarker for diabetic nephropathy in both T1D and T2D, and C4b as well as C1q were found deposited in human kidney samples from diabetic patients, correlating with nephropathy (32). Here, MBL2 is linked to kidney disorder.