TP53 has been found to inhibit glycolysis and to be involved in oxidative stress, the TP53 gene polymorphism marker Pro72Arg has been associated with DPN pathogenesis [64], and TP53 serum levels are significantly increased in patients with T2DM [65], so it is hypothesized that TP53 may play an important role in metabolic diseases such as diabetes. This evidence concerns the gene TP53 and Other metabolic disease.