IGHE and myalgic encephalomeyelitis/chronic fatigue syndrome: Here, we report that miR-486a-5p is a key mediator of IgE-FcεR1 signaling in CFs and has remarkable anti-fibrotic activity in myocardium in vitro and in vivo, consistent with previous studies that show miRNA‐486‐5p is involved in lung fibrosis and hypertrophic scar formation 27, 33.