IRF3 and osteosarcoma: It was revealed that after co-incubation with the osteosarcoma K7 cells pre-treated by GNR-PEI/cGAMP with or without laser irradiation, the BMDCs was effectively activated via a STING dependent signaling pathway marked by the up-regulation of phosphorylated interferon regulatory factor 3 (IRF3), IFN-β and CXC chemokine ligand-10 (CXCL10).