The cGAS-STING pathway was enriched in up-regulated genes in ileum biopsies with CD and in rectum with both CD and UC, which had the same trends as IL-17 signaling pathway 43 and the complement cascade 10 that have been confirmed by overrepresentation enrichment and implicated in the inflamed intestines of IBD (Figure S1C). This evidence concerns the gene IL17A and irritable bowel syndrome.