To explore the effect of cGAS on the gene expression relevant to mouse IBD, we compared the expression of 85 genes in colons, including inflammation, immunity, apoptosis, cell adhesion, and known IBD-related genes, in WT and Cgas-/- mice before and after DSS-colitis on day 9 (Figure 4A, Tables S7 and S8). This evidence concerns the gene CGAS and irritable bowel syndrome.