STING1 and irritable bowel syndrome: The cGAS-STING pathway was enriched in up-regulated genes in ileum biopsies with CD and in rectum with both CD and UC, which had the same trends as IL-17 signaling pathway 43 and the complement cascade 10 that have been confirmed by overrepresentation enrichment and implicated in the inflamed intestines of IBD (Figure S1C).