TLR1 and neoplasm: In this study, we took the advantage of the tumor-associated carbohydrate antigens (TACAs), which are broadly present on the cell surface of malignantly transformed cells and can invoke a T-cell-independent humoral response 34, and the pattern molecular adjuvant Pam3CSK4, which can bind TLR1/2 to activate the innate immune system, in order to eventually elicit a T-cell dependent immune response.