PTGS2 and B-cell chronic lymphocytic leukemia: Based on existing studies on the mt-circRNAs, steatohepatitis-associated circRNA ATP5B regulator (SCAR) plays a pivotal role in mROS metabolism and fibroblast activation, and mc-COX2 modulates mitochondrial function and regulates chronic lymphocytic leukemia cell proliferation and apoptosis 76, 77.