The protein levels of cleaved Caspase-3 and cleaved PARP in hypoxic BC cells increased with MRPL52 downregulation and decreased with MRPL52 overexpression; however, GPX4 (ferroptosis-related index) and Caspase-1 (pyroptosis-related index) did not show changes in expression (Figure 4E). Here, CASP3 is linked to breast cancer.