PRKN and breast cancer: Subsequently, we observed that cell viability and Δψm were decreased and that cell apoptosis and extent of mPTP opening was enhanced in 1% O2-MDA-MB-231-MRPL52 and 1% O2-MCF-7-MRPL52 BC cells transfected with Parkin-SiRNA compared to those transfected with Si-NC (Figure 8E-H).