MVP and osteoporosis: Consistent with the osteoporosis phenotype in Mvp-/- mice, Mvpf/fLyz2-Cre mice also displayed a significant decrease in cancellous bone mass in the distal femurs and calvaria while cortical thickness remained unchanged compared with Mvpf/f controls, which is confirmed by micro-CT analysis and H&E staining (Figure 3A-E, Figure S2C).