HAVCR2 and neoplasm: This analysis showed that genes representing T-cell activation and tumor-killing including Ifng, Vcam1, Rgs1, and Il2rb, had higher expression levels, whereas T-cell exhaustion genes such as Tim-3, Ccl3, Rgs2, and Cd6f3, had lower expression levels in Ogr1−/− mice than that in the WT mice (Fig. 5F).