GPR68 and neoplasm: Tumor growth was evaluated after melanoma cells were implanted into the WT and Ogr1fl/flCD4Cre+/- and Ogr1fl/flCD8Cre+/− mice, demonstrating considerable tumor suppression after Ogr1 abrogation from T cells; this suppression was more obvious in Ogr1fl/flCD8Cre+/− mice (Fig. 3F, G).