According to the Cell Marker database, we distinguished the intratumoral cell and labeled the tumor-relevant cells, including melanoma, tumor endothelial cells, and fibroblasts with SLC45A2. Dendritic cells overexpressing the antigen-presenting molecule (MHCII) were labeled with CD74, neutrophils, and macrophages with S100a9, B cells with Cd79a and CD79b, and lymphocytes represent T cells with Cd3 (Cd3d, Cd3g, Cd3e) (Fig. 2B, C) (Supplementary Fig. 2A). Here, CD3D is linked to neoplasm.