After co-cultured for 24 h, we observed that Ogr1-deficient in CD8+ T cells aggregated around the tumor cells, whereas WT cells were generally scattered and distributed (Supplementary Fig. 3C), also confirming that Ogr1 deficiency not only enhances the ability of T cells to move toward tumor cells but also caused them to kill tumor cells more efficiently (twofold increase) (Fig. 5D). The gene discussed is GPR68; the disease is neoplasm.