ATP2A1 and major depressive disorder: Interestingly, we found that ATP2A1 showed significant transcriptomic-wide association with MDD with weight gain, and this gene was implicated in GWASs of anthropometric traits such as BMI, type 2 diabetes, cognitive abilities, cannabis use, schizophrenia and bipolar disorder, therefore it probably represents a pleiotropic genetic factor regulating both the risk of metabolic and psychiatric disorders [39–43] (Table 1).