TMEM106B and major depressive disorder: Our TWAS findings for anxious MDD found that TMEM106B expression was downregulated in brain tissues, in line with the results of a recent TWAS of MDD [28]; in total, ten of our top findings for anxious MDD (p < 5e-5) were significantly dysregulated in the same study (see Supplementary Table 2 for a comparison of our results with the previous MDD TWAS [28]).