This micro-RNA was found to be altered in MDD [52] and it increases the activity of HSP70 and the NF-κB pathway, which have protective effects during acute stress conditions [53], and also in this case their activity has likely detrimental effects in the long term as they upregulate proinflammatory cytokine expression and cause impaired neurogenesis [54]. This evidence concerns the gene NFKB1 and major depressive disorder.