CCN4 and Hepatic fibrosis: Notably, growing evidence suggests that cyclopamine plays a crucial role in treating liver fibrosis by inhibiting several fibrotic genes.44,45 Similarly, we demonstrated that cyclopamine inhibited WISP-1-induced fibrogenesis in vitro and in vivo, suggesting that Hedgehog-Gli1 signaling is one of the targets of WISP-1 and mediates the fibrotic effect of WISP-1.