CD8A and melanoma: The infiltrated CD8+ T cells from mice breast tumors expressing neo-antigens were isolated and co-cultured with neu-positive tumor cells, subsequently resulting in antigen loss in the neo-positive tumor cells by inducing EMT in them and the acquisition of breast cancer stem cell properties.25 Recent research has shown that certain types of melanoma tumors expressing mesenchymal markers are high in cytolytic immune activity and exhibit improved patient survival,63 suggesting that high cytolytic activity may induce EMT in melanomas.