CD4 and neoplasm: For example, four growth factors (TGFB1, HGF, BMP1 and PDGFB) that are well-known to induce EMT, exhibited higher expression levels in CD4/8+ T cells compared with other immune and tumor cells (Fig. 1F and Supplementary Fig. 1D), suggesting that anti-immune evasion promotes EMT as well by producing growth factors which induce EMT.