Hou et al. (2018) demonstrated that cortical NAD+ levels were decreased in an AD mouse model with introduced DNA repair deficiency (3xTgAD/Polβ + / −), and NAD + supplementation with nicotinamide riboside meaningfully normalised neuroinflammation, synaptic transmission, DNA damage, phosphorylated tau, improved learning, and memory functions. This evidence concerns the gene POLB and DNA repair disease.