The APdE9 mouse model overexpressing the Swedish mutation of APP and PSEN1 deleted in exon 9 have shown to reproduce several AD-related features, i.e. Aβ plaques, deficits in neuronal activity, mild neuritic abnormalities, the impairment of pre- and postsynaptic cholinergic transmission, and elevated mortality15–19. The gene discussed is PSEN1; the disease is Alzheimer disease.