The MHCF1 unique mutations consisted of protein misfolding (Hsp-related genes) and acetylcholine receptor (Chrnb4 and Chrm5) genes that possibly act on cancer cell processes, and tumor suppressor (Adamts1 and Adamts5) and cell cycle (Aurkb and Bub1) genes (Table 3). Here, ADAMTS5 is linked to cancer.