As shown in Fig. 7, the highest fluorescence intensity in the tumor was observed in mice treated with SPION/PVD/MUC1Apt/DOX in comparison with those treated with SPION/PVD/ScrApt/DOX and free DOX, at both 6 and 24 h post-administration, showing the role of MUC1 aptamer in accumulation of the targeted complex in the tumor tissue. Here, MUC1 is linked to neoplasm.