SMAD3 and lung adenocarcinoma: Nevertheless, one previous study has shown that LINC00842 was induced by TGF-β stimulation via the TGF-β/SMAD pathway in TGF-β-responsive cell lines, such as human hepatocarcinoma Huh7 and lung adenocarcinoma A549 cells, and then targeted SMAD3 to promote epithelial–mesenchymal transition40.