SIRT1 and cancer: Overexpressed LINC00842 may directly interact with acetylated PGC-1α, an important transcription co-regulator in the metabolic pathways, and blocks SIRT1 to deacetylate acetylated PGC-1α, resulting in metabolic remodeling, i.e., enhancing anabolism but reducing catabolism in cancer cells (Fig. 7m).