Because adenosine homeostasis has been implicated in the regulation of AMPK activation [31, 32, 47] and since AMPK directly phosphorylates Tau [48], we evaluated the activation/phosphorylation of AMPK (Thr172, designated pAMPK) and Tau phosphorylation in the hippocampi of postmortem Alzheimer’s Disease, FTLD-Tau patients, and Tau22 mice. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.