Even though our study showed increased pTau (T231) colocalized with activated astrocytes by IHC in THY-Tau22 animals when compared to wt animals, the current WB data did not indicate a significant increase in hippocampal tau phosphorylation (at T212, S214, T231, S396, S404, and S422) in THY-Tau22 animals because of HF-diet feeding even at 11 months of age, when the tau pathology was described to be fully developed [7]. Here, MAPT is linked to hydrops fetalis.