VIM and pachyonychia congenita: Furthermore, the protein expression of E-cadherin, which is a marker of cell adhesion, was upregulated in 8505C and TPC1 cells with PC knockdown compared with cells with normal PC expression, while the protein expression of Vimentin was downregulated in 8505C and TPC1 cells with PC knockdown compared with cells with normal PC expression (shown in Fig. 6B).