AKT1 and colonic neoplasm: Huang et al. found that Bifidobacterium can inhibit the inflammatory response in Caco-2 cells infected with Salmonella by inhibiting PI3K/Akt signal, thereby exerting an anti-infective effect [23]; Wang et al. found that Bifidobacterium can down-regulate the expression of survivin in colon cancer LoVo cells by inhibiting PI3K/Akt signal transduction pathway, and up-regulate the expression of p53, and ultimately promote apoptosis.