We observed that despite glioblastoma is affected by a general downregulation of RUNX1T1 and HHIP compared to the normal brain tissue, in the cancer context not all portions of the tumor have a downregulation of these genes but in the more invasive portions the expression of RUNX1T1 and HHIP is higher compared to the other regions. The gene discussed is RUNX1T1; the disease is neoplasm.