We observed that despite glioblastoma is affected by a general downregulation of RUNX1T1 and HHIP compared to the normal brain tissue, in the cancer context not all portions of the tumor have a downregulation of these genes but in the more invasive portions the expression of RUNX1T1 and HHIP is higher compared to the other regions. This evidence concerns the gene HHIP and glioblastoma.