In order to analyze the potential pathogenic mechanism of high-risk patients with gastric cancer, we conducted pathway analysis on the high-risk and low-risk groups through GSEA, and found that the high-risk group was mainly enriched in epithelial-mesenchymal transition (EMT), TGF-β, Wnt /β-catenin, NF-KB/TNF-α signals, etc. These signals are closely related to tumor progression. Here, TNF is linked to gastric cancer.