S100A9 and neoplasm: The clinicopathologic features that were significant in univariate analysis were adopted as covariates in the multivariate analysis, which revealed that S100A9+ cell density in the tumor region or in the nontumoral region was a powerful independent prognostic predictor for OS (Figure 3F; tumor, HR = 1.149; P = 0.036; nontumor, HR = 1.623; P = 0.005).