siRNA targeting Ezrin, a cytoplasmic peripheral protein involved in metastatic spreading of osteosarcoma and dependent on PIP2, also resulted in PLCγ2 upregulation in human osteosarcoma cell lines (155, 156), while another study of osteosarcoma cell lines found PLCγ2 to be a differentially regulated gene (157). This evidence concerns the gene EZR and osteosarcoma.