PLCγ2 is also potentially involved in a small number of solid cancers such as Wilms' tumor (kidney), osteosarcoma, esophageal squamous cell carcinoma, esophageal adenocarcinoma, cervical adenocarcinoma, Birt-Hogg-Dube tumors, non–small-cell lung cancer, and breast cancer. Here, PLCG2 is linked to esophageal squamous cell carcinoma.