NFKB1 and diabetes mellitus: Furthermore, during diabetes, the activation of receptors of advanced glycation end products (RAGE) by AGE and other ligands that trigger RAGE mediate the transcription of NF-κB–dependent pro-inflammatory and cell adhesion molecule coding genes that contribute to endothelial dysfunction and chronic vascular complications and coagulation supported by the increase in vascular hyper-permeability, increased leukocyte adhesion, and extravasation in diabetes [86–89].