The analysis of protein expression and clinicopathological features showed that the cancer invasion of the right surface of prostate gland negatively corresponded with cytoplasm-located E-cadherin expression (r = -0.25, p<0.05) at low level, whereas tumor invasion of the left surface of the prostate gland was negatively associated with the membrane-located expression of E-cadherin (r = -0.26, p<0.05) at low level. The gene discussed is CDH1; the disease is neoplasm.