Both IgG and IgM SOD values were substantially and statistically significantly higher in individuals residing in the Bono East region of Ghana than in their negative control counterparts, residing in blackfly-free areas of Ghana (Accra), supporting the notion that people living in onchocerciasis-endemic communities are exposed to S. damnosum s.l. bites. Here, SOD1 is linked to onchocerciasis.