SCN1B and heart failure: A search of NCBI’s Gene Expression Omnibus (GEO) profile database (42) revealed that SCN1B is upregulated in ischemic cardiomyopathies in human heart [GEO GDS651 and GDS1362 (43)] and mouse heart failure models [GEO GDS411, GDS427 (44), and GDS3660 (45)] (Supplemental Figure 6).